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Notably, previous studies have demonstrated that exposure of SW480 CRC cells to oxaliplatin at a dose of 10 µM, which is 20-fold of the dose that we used to treat HCT116 cells in this study, induced a remarkably low proportion of γH2AX-positive cells ( ΔGSTA4 cells treated with 5-FU and oxaliplatin, which is similar to the rates of apoptosis in HCT116 cells treated with these drugs as reported by other investigators ( ΔGSTA4 -derived xenografts treated with oxaliplatin compared to the untreated group ( Figure 7E )

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Site-selective modification of peptides and proteins via interception of free-radical-mediated dechalcogenation