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In a study on mouse mesenchymal progenitor C 2 C1 2 cells, a ∼500 nm protein-coated commercial GO was internalized through clathrin-mediated endocytosis, while larger GO sheets of 1 μm particle range were taken up through phagocytosis
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A subsequent isolation and amino acid sequence determination of two homogeneous polypeptides from purified non-suppressible insulin-like activity factors (158–160) established the current designation of these molecules as insulin-like growth factors (IGFs) 1 and 2 (161)
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