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For Arbutin_c, it stably interacts with four key residues: D180, E184, S165, and S361 (Table 2)

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A recent study reported that an engineered biohybrid of DH5α Escherichia coli with hypoxia-inducible lactate oxidase and iron-doped zeolitic imidazolate framework-8 nanoparticles enables targeted lactate depletion, immune activation and ferroptosis, significantly inhibiting tumor growth and metastasis (178)

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