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Although DAMP release upon ferroptotic cell death may contribute to the clearance of dying cells, insufficient resolution of DAMPs and other ferroptosis-associated mediators may contribute to development of chronic inflammation and immunopathology
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A noteworthy subset involves replacing the amino functionality with an isosteric atom, such as oxygen (resulting in depsipeptides) or sulfur (yielding thiodepsipeptides) (Figure g)
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