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Adaptor proteins involved in these signaling pathways include, growth factor bound protein2 (Grb-2), Grb-2 associated binding protein 1 (Gab1), PI3K, signal transducer and activator of transcription 3 (STAT3), SH2-containing inositol 5-phosphatase 1 (SHIP1), phospholipase Cγ (PLCγ), SH2 domain-containing tyrosine phosphatase 2 (SHP2) (Liu et al., 2018), and Src homology and collagen homology (Shc) (Saucier et al., 2004)
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[48] strictly, which, in addition to cytomorphological criteria, also considers the level of dermal invasion not determinable by cytological examination
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