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6 The principal mediator is nitric oxide (NO), which activates guanylyl cyclase, thereby increasing concentrations of cyclic guanosine monophosphate

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Pathway research on BPC-157 is synthesised in the review by Seiwerth and colleagues ( Frontiers in Pharmacology , 2021), which covers its reported interaction with the nitric-oxide system and its VEGFR2-associated angiogenic signalling

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