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Interestingly, they are involved in microglial response pathways, which supports a role for CNS immune response and neuroinflammation in the pathophysiology of AD ( Beta-amyloid accumulation in the brain is currently the most commonly accepted hypothesis for the onset of AD pathology, but findings that beta-amyloid is also found in the brain of healthy older adults and that the association between beta-amyloid load and dementia symptoms lessens with age support the contribution of other factors, such as tau accumulation, inflammation, as well as metabolic and cardiovascular factors (106, 112)

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Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart