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The M3R is also expressed on brain microvascular endothelium (Radu et al., 2017), and M3R signaling is also important in adaptive immunity and autoimmunity (indeed, M3R is a candidate receptor for autoantigen recognition by T and B cells) (Sumida et al., 2014)

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One of the most well-known tumor metabolisms is Warburg effect, which tumor cells preferentially utilizing glycolysis for energy production, followed by lactate fermentation in the cytosol, rather than relying on the more efficient process of oxidative phosphorylation in the mitochondria, even in the presence of oxygen [18, 19]