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Furthermore, a notable rise in the expression levels of genes associated with autophagy, as well as a higher quantity of autophagic vacuoles and lysosomes, has been detected in degenerated intervertebral discs and the annulus fibrosus (181, 182)

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In Boyden chamber migration assays, TB4 stimulated keratinocyte migration 2–3-fold over medium alone within 4–5 hours — with as little as 10 pg sufficient to produce a potent stimulatory response