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Consistent with findings demonstrating CD38 is primarily localized to astrocytes within the CNS (Hattori, Kaji et al., 2017, Kou, Banerjee et al., 2009, Roboon et al., 2019, Zhang et al., 2014, Zhang et al., 2016), increases in CD38 immunoreactivity (Fig 1D-G) were observed in GFAP+ astrocytes following either HFD (Fig 1D,F) or lysolecithin-induced demyelination (Fig 1E,G)
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