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Oxidative stress Oxidative stress is widespread to the point of ubiquity in chronic, inflammatory diseases (206,207) , with over fifty papers having the words ‘oxidative’, ‘stress’ and ‘review’ in their titles at PubMed in 2018 alone

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For example, T cells and B cells in GALT can recognize and eliminate translocated bacteria while simultaneously producing anti-inflammatory cytokines such as IL-10 to sustain intestinal immune tolerance (134, 135).Moreover, innate immune cells recognize pathogen-associated molecular patterns via pattern recognition receptors (e.g., Toll-like receptors) and activate signaling pathways like NF-κB, thereby modulating the intensity and duration of the immune response (136)