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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)

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Methods: We identified a single-center retrospective cohort of consecutive acute spontaneous ICH patients (2015-2020) with MRI brain within 30-days of ictus