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Studies in primary endothelial cells grown in culture, as well as in animal models illustrate that a deficiency of GPx1 alters endothelial dependent vasodilation by regulating bioavailable nitric oxide [39, 60, 61, 70, 71]

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[8] [2] A risk-stratified approach ensures efficient use of healthcare resources whilst protecting vulnerable patients

(1)These statements have not been evaluated by the Food and Drug Administration