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Mechanistically, DSIP is intriguing because it appears to cross the blood-brain barrier and has been reported to interact with multiple systems — modulating stress hormones, influencing the hypothalamic-pituitary axis, and showing possible effects on pain perception and thermoregulation

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Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work