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The increase in older people, at least in part, relates to increased life span, increased weight (obesity is associated with gout) and increased use of diuretics

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c-KIT phosphorylation directly activates p38 mitogen-activated protein kinase (MAPK), a member of the MAP kinase family, which in turn phosphorylates CREB and subsequently activates MITF to promote TYR transcription (34)