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Interferon-γ Interferon-γ (IFN-γ) is mainly involved in the regulation of inflammatory immune responses, and levels are elevated in the intestinal mucosa in patients with IBD.39 Recent studies have also demonstrated that IFN-γ increases paracellular permeability in intestinal epithelial cells through the redistribution and expression of TJ proteins and the rearrangement of the actin cytoskeleton.40 Thus, IFN-γ increases actinmyosin contractility in a Rho-associated kinase-dependent manner and induces TJ protein internalization, resulting in intestinal TJ disruption

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10.1111/cod.12037