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subtilis , mutants resistant to purine analogs 8-azaguanine, methionine sulfoxide, and decoyinine increased GTP and riboflavin production because of deregulation in the purine pathway (Schwechheimer et al., 2016)

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Results of subsequent multi-tissue validation demonstrated that, in contrast to the significant increase in FBP1 protein expression observed in the corpus cavernosum following treatment, FBP1 protein expression in the liver and skeletal muscle exhibited an upward trend but failed to reach statistical significance (Supplementary Fig