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Jaiswal, In addition to PII detoxification enzymes, activation of the KEAP1/NRF2, especially by SF, results in an increase in many ARE-dependent AO enzymes (Juge et al., Human clinical evidence of ARE-dependent enzyme induction by sulforaphane The induction of NQO1 by SF not only identified SF as a biologically active component of broccoli but also demonstrated a putative mechanism by which cruciferous vegetables may exert their health promoting benefits (Zhang et al., 1992)

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Doses should be moderate and supervised