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In another randomized study of 75 patients with breast cancer undergoing 12 cycles of post-surgical paclitaxel chemotherapy, oral daily administration of 1,200 mg or 2,400 mg NAC reduced peripheral neuropathy (2,400 mg [28.6%], 1,200 mg [61.9%], control [100%]) and improved quality of life over the 12-week period (Khalefa 2020)
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Therapeutic benefits of maintaining mitochondrial integrity and calcium homeostasis by forced expression of Hsp27 in chemotherapy-induced peripheral neuropathy
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