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Through a consensus-generating approach (Figure 1, Supplementary Appendix S1), the experts (i) discussed the latest scientific findings including existing limitations in health approaches, (ii) identified gaps and untapped potentials in encouraging approaches that have been neglected, (iii) debated the necessity of specific and crucial research priorities, (iv) foresighted policies supporting novel and promising scientific and practical efforts, and (v) weighed on developing practical strategies to promote healthy lifestyle behaviors in everyday scenarios at different levels and settings with a specific emphasis on holistic and integrated health perspectives, particularly the preventative dual approach of “Healthy Eating & Active Living” ( Figure 1 The overarching aim of the congresses, within the context of an international research and knowledge exchange, was to establish direct statements to address today's global health dilemma—in the present context to be understood as a systemic paradox rather than a binary choice—which explores why growing advances in health science and increasing healthcare budgets do not adequately control the increasing prevalence of NCDs

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Likewise, modification of the nicotinamide ribose in NMN and NR led to even more potent covalent and non-covalent inhibitors of CD38 (Figure 4 and Table 2)