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Of the five explanations above for why the evolutionary transsulfuration pathway flux-reversal is advantageous for heterotrophs, the last option, Signaling , is the easiest to correlate to unique metazoan needs, and might be the most important attribute that offset potentially detrimental consequences of being Met-auxotrophic
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10.1021/acs.analchem.6b02553 [DOI] [PMC free article] [PubMed] [Google Scholar] Grigoryan H, Edmands WMB, Lan Q, Carlsson H, Vermeulen R, Zhang L, Yin SN, Li GL, Smith MT, Rothman N, & Rappaport SM (2018)
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