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The MAPK pathway further regulates various transcription factors, including but not limited to HSP27, p38, and c-Myc, which control cell activities such as proliferation, differentiation, and migration (177, 181)

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Moreover, many tumors including PCa cells shed DNA into the serum or other easily accessible body fluids (e.g., semen, urine), simplifying the detection of GSTP1 epimutations in early tumorigenesis stages