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In this light, ageing is followed by a progressive accumulation of random modifications in the function of vital systems in the body, which take place at molecular, cellular and tissue level and are followed by decreased viability and increased morbidity ( It should be noted that alterations in neuroendocrine responses to stress, which are associated with modified HPA axis function, usually accompany ageing ( via up-regulation of the NADPH oxidase in the hippocampus ( Age-related modifications in the CYP-catalyzed drug metabolism It is worth noting that about 50% of drugs are prescribed by clinicians without following age-related guidelines and in only 10% of drugs administered in neonates and infants the safety and efficacy has been evaluated