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No inhibition of HO in the brain of mouse neonates was found after oral gavage of up to 30 μmol ZnBG/kg/BW 3 h after administration, which let us conclude that ZnBG does not pass the blood–brain barrier (He et al., Summary and Conclusion Although Mps have been studied extensively in animal models and some human trials, their safety has not been unequivocally proven yet
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