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Their action can be either IGF-dependent or independent and altered by various post-translational modifications

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These deposits are called tophi (See Figures: 7a and 7b: Tophi on Foot and Over Achilles' Tendon, Figure 8: Tophus on Elbow, Figure 9: Tophi on Hands, and Figure 10: Large Tophus of Finger ) and can be in numerous locations, but especially on the feet and elbows