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Src family molecules such as Shc and Lyn, interact with the cytoplasmic domain of the GHR and activate phospholipase Cγ (PLCγ) which then proceeds to hydrolyse phospholipids to form inositol-1,4,5 triphosphate (IP3) and diacylglycerol (DAG) (47)
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The bulk of published work comes from Predrag Sikiric's group at the University of Zagreb, who have produced the majority of BPC-157 publications over three decades
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