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one or more NNMT inhibitors such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy
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Among these patients, 3 experienced disease progression (PD) during the first treatment cycle, 2 had stable disease, and 2 developed PD after having achieved response (1 partial response [PR] and 1 very good partial response [VGPR]) ( Supplementary Figure S1 )
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