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Furthermore, dysregulation of core clock genes such as CLOCK, BMAL1, PER1/2, CRY1/2, and NPAS2, both at the transcriptional and post-translational levels, is consistently observed in PBMC samples of shift workers and may serve as early predictors of disrupted cell cycle control, DNA repair, and apoptosis

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Nature Reviews Endocrinology , 19(1), 1-15