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After redox equilibration of both redox couples it is possible to equate the two redox potentials (Equation 3): Because E °′ LA is known this leaves two unknowns, E °′ roGFP and [roGFP red ]/[roGFP ox ]
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It is also noteworthy that drugs proposed as non-covalent mechanisms may still contain cryptic electrophilic groups capable of reacting with GSH and serum albumin in vivo [116]
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