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The core concept is that normal components of the tissue (or of the niche where the tumor grows) may provide, either occasionally or as part of a precise neoplastic strategy, a set of soluble factors that contribute to, or even determine, the growth of the tumor itself or facilitate immune evasion

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Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells