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The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration
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The feasible reason for NNMT secreted in the serum of NSCLC and CRC patients or the saliva of OSCC patients is that NNMT can be transported out of the cells via exosomes probably, like the way of producing extracellular NAMPT [126]
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