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Even higher increases in astrocytic α7nACh receptors were found in autosomal-dominant AD, with significant positive correlation between numbers of senile plaques and α7 nACh receptor expression 558

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Concretely, lactylation of PDHA1 at K336 and CPT2 at K457/8 results in the inactivation of both enzymes and the inhibition of OXPHOS by restricting acetyl-CoA influx from pyruvate and fatty acid oxidation, respectively