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They cannot pass through a cell's fatty membrane, so they bind to receptors on the cell surface to send their signals inward

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This limitation is particularly relevant to lipid droplet–mitochondria interactions, because specific tethering assemblies such as PLIN5–FATP4–MIGA2–MFN2 have not yet been directly demonstrated in PACs, and their proposed role in the pancreas is therefore extrapolated from other metabolically active cell types