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While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenter’s ability) to minimize and equalize stress across all animals and reduce confounding variables
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Recent discoveries suggest that NNMT may play important roles in tissue-specific metabolic regulation beyond its established functions in liver and adipose tissue, including potential roles in brain metabolism, immune cell function, and tissue repair processes