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In contrast, the low NNMT expression was reported in liver hepatocellular carcinoma (LIHC), adrenocortical carcinoma (ACC), cholangiocarcinoma (CHOL), kidney chromophobe (KICH), pheochromocytoma and paraganglioma (PCPG), thyroid carcinoma (THCA), and skin cutaneous melanoma (SKCM) [57] (Fig