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For context, tirzepatide demonstrated 22.5% weight reduction in the SURMOUNT-1 trial (NCT04184622) with 2,539 participants over 72 weeks [5]

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Moreover, an impaired interaction between ZO-1, mostly not phosphorylated in CD patients, and β-catenin has been reported, finally, leading to an absent connection between β-catenin and occludin in CD patients (263)