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These factors underlie pronounced species-specific differences in pharmacokinetics and dose-dependent effects, which complicate dose extrapolation from rodent models to livestock species such as pigs
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Mechanical characterization of the microneedles revealed a slight reduction in stress capacity upon melittin loading, with HA microneedles decreasing from 58 MPa to 38 MPa and Mel-HA-MN from 30 MPa to 27 MPa
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