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An additional connection between PD and glucose metabolism derives from the observation of the role of bromocriptine: a DA agonist active on D2 historically used for PD, which was later approved by Food and Drug Administration to treat T2DM ( 2.2 Clinical studies Curiously, an epidemiologic, large-scale, population-based study on 6,800,000 individuals from the database of the Korean National Health Insurance Service observed that being underweight may be a risk factor for the development of PD