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Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), 5-lipoxygenase, modifies COX-2 gene expression and acts as an antioxidant

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The relatively high systemic insulin levels counteract the lipolytic effects of the high GH levels in fat and muscle, but they do not reach adequate levels in the portal vein, so the liver remains under the control of GH, which still induces gluconeogenesis, increasing hyperglycemia [33]

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