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Metastasizing tumor cells must adapt to new metabolic conditions throughout invasion, intravasation, circulation, extravasation, and growth within different microenvironments

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Compared to fibroblasts, macrophage/dendritic cells, endothelial cells, T cells, melanocytes, and pericytes, the activity of lipid oxidation and the Th22/Th17 pathways were highly correlated in keratinocytes (Spearson’s R = 0.614, P = 0.016, Fig